Hey John,
That's some sweet info! Thanks for putting it together. I would not have expected a USB drive on a 2.0 port to run faster than a fast SD card; the manufacturer's specs usually read lower. Proof is in the pudding, though.
Reading more on the Pi forums, I am hearing that Class 10 SD cards are geared for generally higher sequential, single large file read/write rates. (e.g. 1080p recording.) Throw a few small files at them, and they struggle; they are not built for multitasking work, so maybe not the best medium for an OS to begin with. It makes me want to pick up a solid USB flash drive and see how it plays, even with the limited 2.0 ports. But then again, RuneAudio is, from what I understand, a pretty lean system anyways. Maybe it's multitasking needs don't much cramp an SD card's style? Either way, this new Class 10 makes a noticable difference; it's fast enough I can't count on my fingers anymore...
I usually get a high number the first round of debugging. In fact, the first time I debugged after re-flashing the drive, I got 1414198280.651 seconds. So *technically* the debug took 44.8 years. I'll post the results when they get done.

After every re-boot I get a debug time that's notably higher than everything that comes after. Why? I have no idea. Subsequent runs seem to normalize. Of course, this is not a litmus benchmark test, but still useful, I think.
I would be interested in the overclocking, more because I like to fiddle than anything else. Seriously, this thing is already running like a top. I wonder how any of the DAC or DIGI hats would react to it? Somewhere on the forums there was something about running Quake 3 as a test to see how the RPi deals with heating as you incrementally speed it up. I have to assume that RuneAudio is going to have somewhat lower processing needs than a video game, and that pegging the highest recommended speed (I hear 1ghz...) would be just fine for it. More research is required, but let's be honest, this is probably going to happen. Looks like it's worked well for you!
Cheers!
-Fishstix